Benzodiazepines List and Equivalents

BenzodiazepinesHalf-life (hrs)1
[active metabolite]
Market Aim2Approximately Equivalent
Oral dosages (mg)3
Alprazolam (Xanax, Solanax7, Constan7)6-12a0.5
Bromazepam (Lexotan, Lexomil)10-20a5-6
Brotizolam (Lendormin)7a0.25
Chlordiazepoxide (Librium)5-30 [36-200]a25
Clobazam (Frisium, Mystan)12-60a,e20
Clonazepam (Klonopin, Rivotril7, Landsen7)18-50a,e0.5
Clorazepate (Tranxene, Mendon7)[36-200]a15
Diazepam (Valium, Cercine7, Horizon7)20-100 [36-200]a10
Estazolam (ProSom, Eurodin7)10-24h1-2
Etizoram (depas)5,66a1.5
Ethyl loflazepate (Meilax)6122a1.67
Flunitrazepam (Rohypnol, Silece7)18-26 [36-200]h1
Flurazepam (Dalmane, Dalmate)[40-250]h15-30
Halazepam (Paxipam)[30-100]a20
Ketazolam (Anxon)30-100 [36-200]a15-30
Loprazolam (Dormonoct)6-12h1-2
Lorazepam (Ativan, Wypax7)10-20a1
Lormetazepam (Noctamid,Evamir7)10-12h1-2
Medazepam (Nobrium, Resmit7)36-200a10
Nitrazepam (Mogadon, Benzalin7)15-38h10
Nordazepam (Nordaz, Calmday)36-200a10
Oxazepam (Serax, Serenid, Serepax, Serenal7)4-15a20
Prazepam (Centrax, Sedapran)[36-200]a10-20
Quazepam (Doral)25-100h20
Rilmazafone (Rhythmy)10.5h2
Temazepam (Restoril, Normison, Euhypnos)8-22h20
Tofisopam (GRANDAXIN7)0.8a125
Triazolam (Halcion)2h0.5
Anti-benzodiazepines with similar effects4   
Zaleplon (Sonata)2h20
Zolpidem (Ambien, Stilnoct, Myslee7)2h20
Zopiclone (Zimovane, Imovane, Amoban7)5-6h15
Eszopiclone (Lunesta)6 (9 in elderly)h3

  1. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals.

  2. Market aim: although all benzodiazepines have similar actions, they are usually marketed as anxiolytics (a), hypnotics (h) or anticonvulsants (e).

  3. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience but may vary between individuals.

  4. These drugs are chemically different from benzodiazepines but have the same effects on the body and act by the same mechanisms.

  5. This drug is thienotriazolodiazepine but have the same effects as benzodiazepines WITH HIGHEST MARKET SHARE IN JAPAN.

  6. Popular benzos specifically in Japan, not widely spread outside Japan.

  7. The market name available in Japan only.

Reference: Benzo Case Japan , and added Japan's popular benzos and market names ([5], [6], [7])